El Greco first painted the subject in Venice, some years earlier, in the small signed panel in Washington, and he was to take it up again, much later, in Spain, and adhere closely to his original design. As with the Christ Healing the Blind, inspiration for the composition as a whole is from Tintoretto. The main central group, however, is very close to a Michelangelo design, known in drawings, and also in Venusti's painting after Michelangelo's design (National Gallery, London). The figure of the woman walking with a child could be a reminiscence of a similar motif in Raphael's tapestry cartoon, the Distributing of Alms at the Golden Gate. The two men in conversation, who also appear in the middle distance of Christ healing the Blind, have become a grand subsidiary motif, and again hint at acquaintance with Raphael. The larger forms of the architecture also derive from Raphael and Rome, and are consonant with the grander conception of the one integrated action of the main group of figures.The four portraits at the bottom right represent, from left to right, Titian, Michelangelo, Giulio Clovio and possibly El Greco himself. The introduction of Titian and Michelangelo is clearly an acknowledgment of his debt to these two artists. To his friend, Giulio Clovio, he owed his introduction to the Farnese household. The young man looking out, pointing to himself, has similar features to the self-portrait in the Christ healing the Blind at Parma, but the long hair is strange. It has also been suggested that he could represent the young Raphael. The portraits of Titian and Michelangelo (died 1564) were taken from existing portraits, and that of Giulio Clovio follows closely El Greco's portrait of his friend in the Naples Museum, painted c. 1571. El Greco does continue to include portraits in his paintings of religious subjects, but here there is no proper connection with the subject matter.